When someone reports to their doc with high blood pressure they will often be prescribed ACE inhibitors such as enalapril, lisinopril, perindopril and ramipril. Well a new study using pork bones has confirmed what we already know from chicken broth studies. Specifically, that collagen in bone broth also contains a series of amino acids that act in a similar way to ACE inhibitors and can lower blood pressure.
Bone broth is not a supplement, it's a food, a slow food, and as Hippocrates said – "Let food be thy medicine!" That proclamation is really starting to come true now. Bone broth also has the advantage of having no side effects.
Peptides with Potential Cardioprotective Effects Derived from Dry-Cured Ham Byproducts
Marta Gallego, Leticia Mora, Maria Hayes, Milagro Reig, Fidel Toldrá. J. Agric. Food Chem., 2019, 67 (4), pp 1115–1126. DOI: 10.1021/acs.jafc.8b05888
The goal of this work was to determine the presence and stability of peptides showing ACE-I inhibitory activity derived from dry-cured ham bones, which could exert cardiovascular health benefits. ACE-I and DPP-IV inhibitory peptides were stable against heating and in vitro digestion. These results suggest that natural peptides from ham bones could contribute to a positive impact on cardiovascular health.
Angiotensin I-Converting Enzyme-Inhibitory Peptides Obtained from Chicken Collagen Hydrolysate
Ai Saiga et al. J. Agric. Food Chem., 2008, 56 (20), pp 9586–9591. DOI: 10.1021/jf072669w
Peptides with a Gly-Ala-Hyp-Gly-Leu-Hyp-Gly-Pro sequence from chicken collagen had the highest ACE-inhibitory activity. When administered to spontaneous hypertensive rats, a significant decrease in blood pressure (−50 mmHg) was observed after 6 hours, with long-term administration showing sustained suppression of elevated blood pressure.
